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Phase I dose-escalation study of long-acting pasireotide in patients with neuroendocrine tumors.

Onco Targets Ther · 2017 · PMC5499931 · PMID 28721067

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a decreasing trendno p-value reported
Among the biomarkers analyzed, insulin-like growth factor 1 (IGF-1) showed a decreasing trend with increasing pasireotide concentration, while chromogranin A (CgA) and neuron-specific enolase (NSE) levels did not show any dose–response relationship.

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