The reviewers have discussed the reviews with one another and the Reviewing Editor has drafted this decision to help you prepare a revised submission Summary: This is a relatively straightforward but highly significant study demonstrating that chronic lithium administration to mice reduces amphetamine-induced locomotion (a model for anti-manic effects) through a mechanism that depends on BDNF-TrkB signaling, whereas lithium's ability to reduce immobility in the forced swim test (a model for anti-depressant effects) does not depend on BDNF.
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Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling.
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