Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells.

The comparison revealed that, in all the samples analysed and regardless of mutation or diabetes status, several but not all β-cell specific markers including those involved in glucose sensing, regulation of glucose stimulated insulin secretion (thereafter GSIS) and insulin biosynthesis, showed an increasing trend at S7 compared to the previous stage (S6) (Fig. 3a and b ).

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