marginally significantp = 0.049
The SWOG 0226 phase III trial showed a significant improvement in PFS (15 versus 13.5 months; p = 0.007) and marginally significant OS (47.7 months versus 41.3 months; p = 0.049) in favour of fulvestrant plus anastrozole, despite the use of a dose of fulvestrant below the current standard.