24-Month Open-Label Teriparatide Once-Weekly Efficacy Research Trial Examining Bone Mineral Density in Subjects with Primary Osteoporosis and High Fracture Risk.

In a 24-month study of the daily formulation of teriparatide, the BMD of the radius shaft, which consists mainly of cortical bone, decreased significantly at the end of the study, and the distal radius BMDs also showed a decreasing trend [ 1 ], thus the effect on radial BMDs between the once-weekly and daily formulations may be different.

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New results obtained from this study were an increasing trend in BMDs that still persisted after Week 72 and the absence of a trend for a marked increase in the incidence of fractures.

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