Barely Significant
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The interrelationship between phagocytosis, autophagy and formation of neutrophil extracellular traps following infection of human neutrophils by Streptococcus pneumoniae.

Innate Immun · 2017 · PMC5505230 · PMID 28399692

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highly significantno p-value reported
Despite antibiotics and vaccine development, the infection remains a highly significant cause of morbidity and mortality worldwide.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.