Interestingly, this analysis revealed a highly significant overlap between CEH‐23 and CEP‐1 common target genes and the genes that are upregulated by constitutively active AAK‐2, the AMP kinase (AMPK) catalytic subunit homolog in C. elegans (424 Genes) (Fig. 4 A,B, Cluster 1) (Mair et al ., 2011 ).
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Transcription factors CEP-1/p53 and CEH-23 collaborate with AAK-2/AMPK to modulate longevity in Caenorhabditis elegans.
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