highly significantP = 1.5 × 10 −11
Validation of the GRS in the analysis of incident conditions As shown in Table 3 , dGRS 1000 had a highly significant effect (HR = 1.48, 95% CI: 1.32–1.66 per 1 SD; P = 1.5 × 10 −11 ) on the risk of developing T2D during follow-up and accounted for a large set of known covariates.