Barely Significant
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Pleural empyema and streptococcal toxic shock syndrome due to <i>Streptococcus pyogenes</i> in a healthy Spanish traveler in Japan.

IDCases · 2017 · PMC5506862 · PMID 28725562

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highly significantno p-value reported
Further, a retrospective study of molecular features of these invasive strains showed a highly significant association of the presence of speA gene (encodes a streptococcal pyrogenic exotoxin [superantigen]) with the onset of STSS [14] .

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