Environmental bacteriophages active on biofilms and planktonic forms of toxigenic Vibrio cholerae: Potential relevance in cholera epidemiology.

The difference in survival rate between biofilm associated cells and corresponding planktonic cells was apparent after 2h of incubation with the phage, and after 5h of incubation the difference between the survival of biofilm associated cells as compared to planktonic cells was highly significant both for phage JSF4 (p = 0.0090) and for JSF3 (p = 0.0066).

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Considering the immense number of phages which exist in the aquatic environment, it seems highly likely that the occurrence of biofilm-degrading phages is more common, and their collective effects may be significant.

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