Position effects influencing intrachromosomal repair of a double-strand break in budding yeast.

Previously we have shown that increasing homology from 1 kb to 2 or 3 kb on each side of the DSB had a very significant effect on the efficiency of ectopic DSB repair [ 2 ]; the data here are consistent with the idea that sharing more extensive homology, even if interrupted on one side by a heterology [ 5 , 10 ], has a highly significant effect on the likelihood that a donor will be successful in repairing the DSB, but the intrachromosomal site remained the preferred donor.

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