Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles.

PLoS Genet · 2017 · PMC5507469 · PMID 28650991

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highly significantp = 6.52 x 10 −7actually significant

This correlation of function with polymorphism is highly significant for HLA-A ( p = 6.52 x 10 −7 ) and HLA-B ( p = 1.18 x 10 −6 ), but less so for HLA-C ( p = 0.0124) (2 x 2 Fisher’s Exact test).

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