Our data suggest that there may be significant deleterious effects of this persisting IH, but future studies in human infants born preterm are needed to determine if persisting IH due to immature breathing also causes acute injury and more importantly, whether this acute injury is associated with long term neurodevelopmental impairment.
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Early postnatal exposure to intermittent hypoxia in rodents is proinflammatory, impairs white matter integrity, and alters brain metabolism.
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