Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis.

Sci Rep · 2017 · PMC5509675 · PMID 28706201

Europe PMC DOI

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP < 1.0e-183actually significant

We found the DHCR7 lead SNP rs2852853 interacted with cohort (P = 2.0e-02) as well as gender (P = 2.6e-03), and the HLA-DQB1 lead SNP rs9275428 interacted with cohort (P = 6.1e-04), where cohort and gender were both highly significant environmental factors in the logistic regression models based on Equation 2 in the Methods section (P < 1.0e-183 and P < 1.0e-64 respectively).

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marginally significantno p-value reported

When adjusted for multiple tests of four vGWAS signals per E (P = 0.05/4), these GxE interactions were either insignificant or marginally significant each carrying only weak/moderate effects in general.

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