Because we observed a nonsignificant trend toward reduced ATF4 in mouse PCNs cultured for 11 DIV (data not shown), it is possible that a more pronounced reduction would be observed in cells cultured for longer periods of time or challenged with a reduced concentration of thapsigargin.
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Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APP<sup>Swe</sup> Mouse Models of Tauopathy and Amyloidosis.
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