Exosomes derived from pancreatic cancer cells induce insulin resistance in C2C12 myotube cells through the PI3K/Akt/FoxO1 pathway.

Statistical significance was set as follows: a P value of 0.05 was significant, and a value of 0.01 was highly significant.

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Subsequent studies indicated an increased level of FoxO1 nuclear translocation that was induced by KPC-exosomes, while Phospho-FoxO1 showed a decreasing trend (Fig. 4A and B ).

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The nuclear FoxO1 levels displayed an increasing trend (normalized to the nuclear protein Lamin A/C levels; Fig. 4A ) in contrast to the nuclear Phospho-FoxO1 levels (Fig. 4B ).

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