Long-term outcomes and toxicities of a large cohort of anal cancer patients treated with dose-painted IMRT per RTOG 0529.

Although the statistically significant association of nodal status and treatment duration with EFS was lost on multivariable analysis, there was a trend toward significance with P -values in the .06 to .07 range, which suggests that this lack of significance may be secondary to limited power.

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On multivariate analysis for EFS, only advanced T-stage remained significant (hazard ratio, 4.9; 95% confidence interval, 1.75-13.89; P = .003) although LN involvement and treatment duration were borderline significant ( Table 4 ).

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