Endothelial Dysfunction in Severe Preeclampsia is Mediated by Soluble Factors, Rather than Extracellular Vesicles.

Sci Rep · 2017 · PMC5517616 · PMID 28725005

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Angiogenic protein expression in total-conditioned, EV-depleted and EV-enriched media Total media analysis by ELISA demonstrated a highly significant reduction in PlGF secretion by sPE placental villi compared to preterm or term conditioned media (sPE = 70 ± 18 pg/mL, preterm = 338 ± 203 pg/mL, term = 188 ± 94 pg/mL, p = 0.03, n = 4) (Fig. 3A–C ).

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