Barely Significant
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Resin infiltration of deproteinised natural occlusal subsurface lesions improves initial quality of fissure sealing.

Int J Oral Sci · 2017 · PMC5518973 · PMID 28621326

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highly significantno p-value reported
Adhesive sealing of fissures using (un-)filled composite resins (CRs) has proven to be a preventive strategy with high efficacy 1 and highly significant caries reduction rates. 2 In specimens sealed clinically, bacteria located in the fissures were entrapped or explicitly reduced 3 by the sealing procedure, thus indicating that any microbial activities will be stopped.

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