Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study.

With regard to the biomarkers of inflammation (Table 5 ), compared to celecoxib, patients with levels of HA lower than the median treated with chondroitin sulfate demonstrated less cartilage volume loss in the medial condyle ( p = 0.047), with a numerical trend toward significance in the compartment ( p = 0.083).

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