Extracellular survivin might be significant for the pathogenesis of inflammation as previously reported in human leukocytes in the context of autoimmune arthritis 56 or asthmatic pregnancy. 57 In its extracellular context, survivin modulates T-cell responses, skewing immunity towards a Th2 response 58 similar to the phenotype observed in obese patients where leptin resistance is developed. 59 Moreover, downregulation of survivin results in a decrease of IL-6 production by human monocytes. 60 Overall, an additional function of survivin in modulation of inflammatory state in obesity should not be ruled out.
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Survivin, a key player in cancer progression, increases in obesity and protects adipose tissue stem cells from apoptosis.
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