Peripheral Inflammation, Apolipoprotein E4, and Amyloid-β Interact to Induce Cognitive and Cerebrovascular Dysfunction.

Consistent with the behavioral deficits, there was a nonsignificant trend in which, compared to PBS, LPS treatment resulted in lower levels of the postsynaptic protein PSD-95 in the cortex of E4FAD+ mice ( Figure 2(c) ; p = .088).

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