Interestingly, cher Q1042x in combination with sls ZCL2144 resulted in a highly significant enrichment of actin at the H-zone ( Fig 6B and 6G ). cher Δ5 and cher Q1415sd in combination with sls ZCL2144 also led to strong H-zone actin accumulation ( Fig 6C, 6D and 6G ).
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Filamin actin-binding and titin-binding fulfill distinct functions in Z-disc cohesion.
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