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Therapeutic effects of sphingosine kinase inhibitor N,N-dimethylsphingosine (DMS) in experimental chronic Chagas disease cardiomyopathy.

Sci Rep · 2017 · PMC5522404 · PMID 28733584

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Additionally, DMS treatment increased the activation of Nlrc5 and Nlrx1 genes, and had an increasing trend of expression of Nlrp4 , Nlrp5 , Nlrp6 , Nlrp9 genes when compared to T. cruzi -infected cells (Fig. 7B ).

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