) challenge and 2-DG treatment in vitro ( Fig 5A and 5B ) showing a highly significant and dose-dependent reduction in IL-10 secretion after co-incubation with 2-DG ( Fig 5A ) with an increase in IL-12p40 secretion ( Fig 5B ). 2-DG reduces bacterial burden and granulomatous lesions in liver and spleen of L . m .-challenged BALB/c mice To further evaluate the physiological relevance of the altered cytokine production mediated by 2-DG, we tested the effect of 2-DG in a well-established mouse infection model.
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Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis.
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