borderline significantP = 0.10
25 Here, we measured the initial slope of this pH i recovery as an indirect measure of the apparent Na + /H + exchanger activity, revealing that there is a borderline significant difference between Slc4a11 +/+ and Slc4a11 −/− MCECs ( Fig. 3 C, paired t -test, 2-tailed P = 0.10, 1-tailed P = 0.05, n = 3 in each group) that can be attributed to Slc4a11 proton permeability. 25 H + -lactate − cotransporter: Because we recently demonstrated that lactate transport is a significant component of the corneal endothelial pump, 36 we next examined the lactate-dependent H + fluxes in MCECs.