Genetic polymorphisms predict response to anti-tumor necrosis factor treatment in Crohn's disease.

World J Gastroenterol · 2017 · PMC5526766 · PMID 28785150

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

borderline significanceP = 0.058so close (0.05 < p ≤ 0.1)

In univariable analyses, the Fas ligand SNP (rs763110) demonstrated a difference between ever-responders and non-responders with borderline significance ( P = 0.058) and significance when grouping TC and TT genotypes together ( P = 0.020).

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a trend towards significanceno p-value reported

Separately, -308 (rs1800629) when examined by itself demonstrated only a trend towards significance, but when combined with disease behavior and perianal disease, a significant correlation was demonstrated ( P = 0.049, OR = 2.88, 95%CI: 1.01-8.22).

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