Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors.

Mol Oncol · 2017 · PMC5527463 · PMID 28306192

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highly significantno p-value reported

A highly significant finding of the study was that both MDA‐435R and MDA‐231R cell lines were also cross‐resistant to HSP90 inhibitors structurally unrelated and chemically distinct to the BAs, including radicicol and next‐generation HSP90 inhibitors CCT018159, VER50589 and AUY922.

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