Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function.

In contrast, both upstream and downstream flanking regions have a much higher level of methylation (average 0.72), which is highly significant ( p = 4.86 × 10 −20 and p = 1.71 × 10 −21 , respectively, Wilcoxon rank-sum test) (Additional file 4 ).

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