highly significantp < 0.0001
described that the ACQ score significantly decreased from 3.58 ± 1.28 to 2.01 ± 1.05 after 16 weeks (−43.7%), treatment responders showed greater and highly significant improvements of symptoms compared with non-responders even after 16 weeks (−46.9%, p < 0.0001 vs −36.1%, p < 0.05) [ 16 ].