However, in view of the efficient cleavage of all three human CXCR3 agonists, our observed GAG-mediated protection may be highly significant depending on the local conditions in specific human tissues.
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Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling.
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