Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators.

Importantly, under each browning condition, the overlap between transcription factor (TF)s’ occupation sites and the up-regulated gene’s promoters was highly significant for both mRNA and lncRNA genes, with the strongest overlap observed for the 4°C treatment (FDRs in the range of 5.3 X 10 −3 to 2.2 X 10 −16 for mRNAs and 2.6 X 10 −1 to 1.32 X 10 −4 for lncRNAs) ( Fig 1J ), suggesting that PparΥ and Prdm16 are likely to play a role in regulating mRNA and lncRNA expression.

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