Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion.

Conclusion In this short pilot investigation, 1 week of maximally titrated ACEi did not impact PTH in participants without P-HPT, but resulted in a modest and marginally significant reduction of PTH but not calcium, among participants with P-HPT.

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Discussion In this single-arm pilot study examining the effect of ACE inhibition on PTH levels in normal and primary hyperparathyroidism participants, we found that one week of lisinopril therapy titrated to maximally tolerated blood pressure lowering resulted in a modest and marginally statistically significant lowering of PTH levels among participants with P-HPT without any detectable change in calcium.

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