The mutation of Trp64Arg in β3-adrenoreceptor-encoding gene is significantly associated with increased hypertension risk and elevated blood pressure: a meta-analysis.

Integral analyses of 21 individual studies revealed that the mutation of ADRB3 gene Trp64Arg polymorphism was associated with the significantly increased risk of hypertension under three genetic models mentioned above, in company with moderate or marginally significant heterogeneity as gauged by the I 2 statistic (Figure 2 ).

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