Pathophysiology of major depressive disorder: mechanisms involved in etiology are not associated with clinical progression.

Severity of depression showed a significant negative association with the AUCg level ( β =−0.086, s.e.=0.040, P =0.034), and the number of episodes showed a borderline significant association with CRP in women ( β =−0.067, s.e.=0.034, P =0.050).

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Vitamin D: Both unadjusted and adjusted vitamin D levels showed a highly significant linear trend across the three main groups, with the at-risk group having significant lower vitamin D levels than the HCs and the full-threshold MDD group having significant lower vitamin D levels than the at-risk group.

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