Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression.

Crtc1 −/− male mice had increased levels of Agmat protein in the HIP ( t =−2.72, df=6, P =0.036), whereas a nonsignificant trend ( t =−1.51, df=9, P =0.152) of increased Agmat was observed in the PFC ( Figure 1d ).

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