15q13.3 homozygous knockout mouse model display epilepsy-, autism- and schizophrenia-related phenotypes.

21 There was a nonsignificant trend in the same direction in Df(h15q13) +/− mice, but this is not supported by previous work in another hemizygous 15q13.3 deletion mouse model. 10 The three-chambered social-approach assay quantifies how much time the mice use exploring a novel mouse, which can be interpreted as social interest, but it does not qualitatively assess social behavior. 23 Thus, it indicates a social behavior abnormality of Df(h15q13) −/− mice, but further studies are needed to describe this in detail.

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