Caffeine as an opioid analgesic adjuvant in fibromyalgia.

J Pain Res · 2017 · PMC5546775 · PMID 28814895

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marginally significantno p-value reported

Mood disturbances are a major component of FM and our results suggest caffeine use had a significant or marginally significant positive impact on depression in both opioid strata.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.