Nano-sized cytochrome P450 3A4 inhibitors to block hepatic metabolism of docetaxel.

Although it is generally considered that a fivefold difference of IC 50 is considered acceptable between two CYP450 activity assays, difference among nanocarriers may not be significant. 18 HepaRG cells do express ASGPR, a specific receptor at the surface of hepatocytes, receptor of Ga and lactosyl. 37 A differential uptake of functionalized versus unfunctionalized micelles and nanoparticles was qualitatively observed in vitro by confocal imaging.

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