Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits.

PLoS Genet · 2017 · PMC5550000 · PMID 28746338

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closest p · 0.0× alpha

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marginally significantP = 1.09 × 10 −10actually significant

For PLINK, a single SNP was deemed marginally significant if it belonged to a epistatic pair with a p-value below the genome-wide threshold P = 1.09 × 10 −10 (i.e.

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marginal significanceno p-value reported

While using the genetic relatedness matrix K cis , MAPIT identified a total of 3,434 mepiQTL across 228 different mepiGenes that satisfied this marginal significance rule.

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