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Characteristics and national trends of patients receiving treatment of the primary tumor for metastatic prostate cancer.

Prostate Int · 2017 · PMC5551914 · PMID 28828351

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an increasing trendno p-value reported
Conversely, there was an increasing trend in the use of ADT for newly diagnosed metastatic patients.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.