The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome.

Aging (Albany NY) · 2017 · PMC5559174 · PMID 28768896

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highly significantno p-value reported

Since CR studies seldom exceed 40% restriction (reviewed in [ 139 ]) and at this level there is a highly significant impact on lifespan, these data suggest Fgf21 is unlikely to be a significant mediator of the CR effect on lifespan.

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