Comparison of chronic physical and emotional social defeat stress effects on mesocorticolimbic circuit activation and voluntary consumption of morphine.

3A,D : F (2,26) = 2.51, p = 0.10) was a nonsignificant trend, the number of cFos-positive cells was significantly decreased in the CPu (Fig. 3B,E : F (2,30) = 7.871, p = 0.0018) and the dorsal hippocampus (CA3) (control: 100 ± 10.3, PS: 80.7 ± 11.1, ES: 59.5 ± 9.7; F (2,30) = 3.761, p = 0.0349) of ES mice compared to controls, with a similar non-significant trend observed in the dorsal DG (Fig. 3C,F : F (2,30) = 3.217, p = 0.0542).

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