Therefore, the presence of QVOA wells containing low levels of RNA (i.e., <50 SIV RNA copies/ml or 10 copies/reaction) may be significant in evaluating BrMΦ latent reservoirs for “shock and kill” strategies since low levels of potentially replication-competent latent genomes could contribute to virus rebound.
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Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir.
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