Moreover, when promoter occupancy of Pol I and UBF was compared between PGC-1α competent wild-type and PGC-1α knock-out tissue, we found a highly significant difference of Pol I and UBF binding to the rDNA promoter after precipitating the same amount of protein (Fig. 3b ).
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Ribosomal transcription is regulated by PGC-1alpha and disturbed in Huntington's disease.
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