ESCRT-III Membrane Trafficking Misregulation Contributes To Fragile X Syndrome Synaptic Defects.

This suggests a similar endocytic membrane trafficking defect. Using the Rab5 endosomal marker in quantified comparisons, both dfmr1 null mutants (0.1 ± 0.03 μm 2 , n = 23 boutons, p < 0.001) and PN-targeted shrub OE GOF (0.04 ± 0.01 μm 2 , n = 29, p < 0.01) show highly significant increases in the number of endosomes per synaptic bouton area compared to controls (Fig. 3C ).

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