Time on the rod of the isradipine treated mice from the 1- and 2-week treatment subgroups also showed an increasing trend, however, no significant changes were observed (* P < 0.05, *** P < 0.001 compared with control; # P < 0.05 compared with MPTP treatment group, n = 10).
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Isradipine attenuates MPTP-induced dopamine neuron degeneration by inhibiting up-regulation of L-type calcium channels and iron accumulation in the substantia nigra of mice.
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