Novel biomarkers for prediabetes, diabetes, and associated complications.

Furthermore, miR-192 and miR-193b have been correlated with Tg levels and the fatty liver index in animal models, 120 which may be significant as a fatty liver can be associated with prediabetes. 123 Moreover, exercise was shown to significantly decrease miR-192 and miR-193b concentrations. 120 Other miRNAs significantly elevated in T2DM include miR-9, miR-29a, miR-30d, miR-34a, miR-124a2, miR-146a, and miR-375, all thought to play a role in β-cell function.

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However one multi-ethnic US study found a positive trend in those with IFG or diabetes. 74 FetA may be associated with higher risk of CVD in those susceptible to the development of IR. 74 Taken together, these findings suggest that FetA is an endogenous ligand for TLR4 through which lipids induce IR.

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