Patients double-seropositive for ANCA and anti-GBM antibodies have varied renal survival, frequency of relapse, and outcomes compared to single-seropositive patients.

There was a highly significant difference in the degree of interstitial fibrosis and tubular atrophy between these 2 groups, with more evidence of chronic damage in double-positive cases (median: 27% vs. 5%, P < 0.001).

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