Why statistical inference from clinical trials is likely to generate false and irreproducible results.

Another highly significant prognostic factor is the intrinsic aggressiveness of the disease; however, its reliable assessment at early stages of the disease has proven so far to be elusive.

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The correction to the assumed asymptotic distribution with an infinite tail that arises from such a truncation, as measured by some probability metric, may be small; however, the downstream effects of this error on the distribution of the test statistic and outcomes of statistical analysis may be significant.

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